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. 2016 Jun;6(2):181–190. doi: 10.1086/686020

Table 2.

Noninvasive metrics’ individual accuracies evaluated for a cutoff value corresponding to maximum Youden index

Noninvasive PH markers (data-driven threshold) AUC Misclassification error Sensitivity Specificity Threshold
1D model
 Wb/Wtot 0.88 0.25 0.68 1 0.35
0D model
 Rd, mmHg s/mL 0.85 0.25 0.72 0.87 0.45
 Rc, mmHg s/mL 0.67 0.38 0.56 0.86 0.01
 C, mL/mmHg 0.83 0.25 0.72 0.87 0.88
PA imaging
 RAC, % 0.81 0.29 0.67 0.87 16
 CMR
 RVMI, g/m2 0.81 0.26 0.68 0.93 16.01
 RVEDVI, mL/m2 0.64 0.51 0.36 0.93 0.94
 VMI 0.73 0.26 0.74 0.73 0.27
 RVEF, % 0.74 0.38 0.56 0.87 43
 Systolic septal angle, degrees 0.81 0.35 0.56 1 164
Note

PH: pulmonary hypertension; AUC: area under the curve; 1D: one-dimensional; Wb/Wtot: ratio of backward to total wave power; 0D: zero-dimensional (Windkessel); Rd: distal resistance; Rc: characteristic resistance; C: total pulmonary compliance; RAC: relative area change of main pulmonary artery (PA); CMR: cardiac magnetic resonance; RVEDVI: right ventricle end-diastolic volume index; RVEF: right ventricle ejection fraction; VMI: ventricular mass index; RVMI: right ventricle mass index.