Table 2.

Odds ratios and 95% confidence intervals for CIN 2+, CIN 3, and 8-OH status according to cervical mucosa community type

Community type	Partition 1	Partition 2	Partition 3	Partition 4
π (θ)*	0.15 (7.74)	0.41 (89.78)	0.16 (282.98)	0.28 (55.59)
CIN 2+ vs. CIN 1
Total number (% CIN 2+)	62 (73%)	170 (81%)	68 (87%)	119 (76%)
Unadjusted model	1.00	1.63 (0.83; 3.21)	2.48 (1.01; 6.07)	1.17 (0.58; 2.36)
Multivariable model†	1.00	1.84 (0.86; 3.93)	3.48 (1.27; 9.55)	1.13 (0.51; 2.52)
CIN 3+ vs. CIN 1
Total number (% CIN 3)	34 (50%)	78 (59%)	32 (72%)	65 (55%)
Unadjusted model	1.00	1.44 (0.64; 3.23)	2.55 (0.92; 7.10)	1.24 (0.54; 2.85)
Multivariable model†	1.00	1.68 (0.66; 4.28)	3.24 (0.98; 10.68)	1.20 (0.45; 3.20)
8-OHdG (>38.8% vs. <=38.8%, median)
Total number (% above median 8-OHdG)	30 (40%)	42 (57%)	27 (63%)	57 (44%)
Unadjusted model	1.00	2.00 (0.77; 5.18)	2.55 (0.88; 7.43)	1.17 (0.48; 2.88)
Multivariable model‡	1.00	2.23 (0.82; 6.07)	2.61 (0.85; 8.03)	1.42 (0.53; 3.79)

Abbreviations: CIN, cervical intraepithelial neoplasia; 8-OHdG, 8 hydroxy deoxyguanosine.

Notes: Partitioning of samples was performed using the Dirichlet multinomial mixture model (cite) as implemented in Mothur v1.35 (cite).

^*π reflects proportion of samples clustered to the community type. θ reflects variance with small values reflecting greater variation.

^†Adjusted for age, BMI, race, education, parity, hormonal contraceptive use and smoking status.

^‡Adjusted for age, BMI, race, education, parity, hormonal contraceptive use, smoking status, and CIN status.