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. Author manuscript; available in PMC: 2016 Nov 11.
Published in final edited form as: Nature. 2016 May 11;533:212–216. doi: 10.1038/nature17672

Figure 4. AR proteins found in multiple habitats and genetic contexts in RES and PST.

Figure 4

a, Representative alignment of 5 of 25 contigs encoding a TEM-type β-lactamase at 99.9% nucleotide identity (full list of contigs in Methods). Contigs were annotated with Resfams v1.2. Source metagenomic libraries are indicated on the left. b, AR networks between human and environmental metagenomes in RES and PST. Small nodes (squares) represent unique AR proteins found in at least one sampled metagenome, colored by predicted resistance mechanism. Large nodes represent individual human/animal (circle) or environmental (triangle) metagenomes, colored by habitat/cohort. Lines connecting samples and AR proteins represent a ShortBRED hit with an RPKM (reads per kilobase per million reads) of ≥10, colored by mechanism.