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. Author manuscript; available in PMC: 2016 Aug 3.
Published in final edited form as: Sci Transl Med. 2016 Feb 3;8(324):324ra16. doi: 10.1126/scitranslmed.aad3305

Fig. 2. General status of iKO mice.

Fig. 2

(A) Life span of Ctrls and iKOs with medians of 745 days and 765 days, respectively (log-rank test; P=0.9852). (B) Body weight of Ctrls and iKOs for both genders (Student’s t-test; ns, no significant difference). (C) The ratio of organ to body weight in 5-month-old and 11-month-old old Ctrls and iKOs (multiple t-tests with Holm-Sidak correction; **, P<0.01). (D) Fertility analysis in both male and female Ctrl, iKO, and untreated Cre+ mice (χ2 test; ns, no significant difference; **, P<0.01; ***, P<0.001). (E) Blood glucose concentrations of Ctrls and iKOs that underwent GTT and ITT (N=6 to 7, 2-way ANOVA; no significant difference between Ctrls and iKOs at any time point).