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. Author manuscript; available in PMC: 2016 Aug 3.
Published in final edited form as: Sci Transl Med. 2016 Feb 3;8(324):324ra16. doi: 10.1126/scitranslmed.aad3305

Fig. 4. HFD-induced atherosclerosis.

Fig. 4

Both (A) cKO and (B) iKO mice and their littermate controls were in a LDLR−/− background and fed with a HFD (42% kcal from fat) from 12 w of age. 16 w after HFD treatment, mice were euthanized and whole aortas were dissected and stained with oil red O. Plaque areas (shown in red) were quantified with Image-Pro. The percentage of plaque area relative to the entire area was calculated (Student’s t-test; *, P<0.05; **, P<0.01; ***, P<0.001).