Skip to main content
. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Transplantation. 2016 Feb;100(2):325–333. doi: 10.1097/TP.0000000000000961

FIGURE 3.

FIGURE 3

Development of fibrosis. A, mRNA expression of collagen I in the kidney: the mRNA expression of collagen I significantly increased in both CNI-treated groups. In contrast, Aliskiren treatment prevented the increased collagen production. Panel B, localization of striped fibrotic islands in the kidney: Masson trichrome staining revealed only a weak collagen staining around the arterioles in controls, but hardly any interstitial staining was detected. However, 3-week CNI treatment resulted in significant elevation of collagen amount (arrows) referring to fibrosis in both groups, mostly in the close proximity of collecting ducts (¤). Administering direct renin inhibitor Aliskiren the amount of collagen reduced to the level of controls. (n = 3-5/group) *P ≤ 0.05 versus control, #P ≤ 0.05 versus Alisk. Black: nuclei; red: cytoplasm and erythrocytes; blue: collagen.