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. Author manuscript; available in PMC: 2017 May 17.
Published in final edited form as: Biochemistry. 2016 May 3;55(19):2748–2759. doi: 10.1021/acs.biochem.6b00167

Figure 8.

Figure 8

Structural change in ToxA after ordering of the N-terminal segment. (A) Cα traces of ToxA structures with an ordered (light green) or disordered (salmon) N-terminal segment after superimposition of the Class I methyltransferase domain. Phe17 in the N-terminal segment and Phe179 and Phe187 in the flap domain are also shown. The arrow highlights the displacement in the substrate recognition domain. (B) Close-up view of hydrophobic interactions between the N-terminal segment and flap domain. The position of Phe179 in the ToxA structures having a disordered N-terminal segment would lead to a steric clash with Phe17.