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Tyr7 of ToxA occupies a structurally conserved tyrosine site in various methyltransferases. Superimposition of ToxA (green) onto (A) glycine N-methyltransferase (purple), (B) vaccinia virus mRNA cap methyltransferase (purple), and (C) a Type I protein arginine methyltransferase (purple). For clarity, the substrate recognition domains are not shown. Superimpositions were based on SAH/SAM coordinates. SAH and SAM are represented with balls and sticks.
