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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Brain Res. 2016 Feb 10;1640(Pt A):57–76. doi: 10.1016/j.brainres.2016.02.006

Figure 1. Chain reaction of lipid peroxidation.

Figure 1

Chain reaction of lipid peroxidation involves a three step pathway: 1) initiation - removal of a hydrogen from PUFAs to form a carbon-centered lipid radical; 2) propagation - attachment of a peroxy group to the lipid radical to form a lipid peroxyl radical. This lipid peroxyl radical initiates a new cycle by extracting a hydrogen, thereby perpetuating the peroxidation reaction; and 3) termination - disappearance of free radical by forming a non-radical such as hydroxide.