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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Brain Res. 2016 Feb 10;1640(Pt A):57–76. doi: 10.1016/j.brainres.2016.02.006

Figure 3. Biosynthetic pathways of specialized pro-resolving lipid mediators (SPMs).

Figure 3

Free fatty acids produced after the hydrolysis of phospholipids such as phosphatidylcholine (PC), phosphatidylserine (PS), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) are modified by either LOX or acetylated COX to produce the hydroperoxy fatty acids. Hydroperoxy arachidonic acids are directly converted into lipoxin and epi lipoxin by the LOX enzyme, and Hydroperoxy EPA is converted into Resolvin E1, and E2. In the case of hydroperoxy DHA, further conversion to epoxy products and consequently into maresins and resolvin D1, D2 occurs.