Table 1.

Cyclooxygenase inhibitors in acute brain injury

Sl. No	Compound	Species	Injury	Effect	Ref
1	Ibuprofen	Mice	TBI, Fluid percussion	No effect	(Harrison et al., 2014)
2	Indomethacin	Rats	TBI, Fluid percussion	Reduced mortality due to more rapid return to normal breathing after the apneic period post-TBI.	(Kim et al., 1989)
3	Nimesulide	Rat	TBI, impact acceleration diffuse TBI	Substantial improvement in cognitive function	(Cernak et al., 2002)
4	Meloxicam	Rat	TBI, Mild weight drop	Reduced MDA, cerebral edema, blood brain barrier (BBB) permeability, restored glutathione levels, improved neurological score at 48h.	(Hakan et al., 2010)
5	Indomethacin	Mice	TBI, Weight drop	Reduction in brain 6-Keto PGF1α levels (6 h) and neurodeficit, no effect on brain edema	(Girgis et al., 2013)
6	Carpofen	Mice	TBI, Weight Drop	Reduced lesion size; water content and number of microglia in the lesioned cortex; lowered the levels of proinflammatory cytokines and improved functional outcome	(Thau-Zuchman et al., 2012)
7	Celecoxib	Rat	TBI, Weight drop	No effect on the neurological score or the brain water content	(Girgis et al., 2013)
8	Meloxicam	Mice	TBI, Weight drop	No effect on the neurological score or the brain water content	(Girgis et al., 2013)
9	Lornoxicam	Rats	TBI, weight drop diffuse TBI	Reduced brain edema but did not affect BBB permeability	(Topcu et al., 2013)
10	Nimesulide	Rat	Trauma, Impact acceleration	Improved memory (Barnes maze) and motor (rotarod) performance after neurotrauma	(Cernak et al., 2001)
11	Roficoxib	Rat	TBI, FPI	No effect on hippocampal neuronal death	(Kunz et al., 2006)
12	Indomethacin	Human	TBI, Head-injured patients	Decreased ICP as well as cerebral blood flow and temperature	(Jensen et al., 1991)