Table 2.

Lipoxygenase inhibitors in acute brain injury

Sl. No	Compound	Species	Injury	Effect	Ref
1	MK-886, Boscari ®	Rat	TBI, controlled cortical impact	Reduced lesion volume and neuronal death	(Voigt et al., 2012)
2	MK-886, Boscari ®	Rat	TBI, controlled cortical impact	Reduced inflammatory response in a region specific manner	(Hartig et al., 2013)
3	MK-886	Rat	TBI, unilateral moderate fluid percussion injury	Reduced brain edema, attenuated blood brain barrier	(Corser-Jensen et al., 2014)
4	SK&F 105809	Rat	TBI, weight drop	High dose attenuated brain edema	(Shohami et al., 1992)
5	LOXBlock-1,3	HT22 Cell, Rat primary neuron, Oligodendrog lial Cells	Cell, glutamate toxicity	Protection Against Oxidative Glutamate Toxicity	(van Leyen et al., 2008)
6	Baicalein	HT22	Cell, Iodoacetic acid toxicity	Attenuated cell death	(Lapchak et al., 2007)
7	MCI-186	Rat	Ischemia, permanent left internal carotid artery occlusion	Attenuated brain edema	(Nishi et al., 1989)
8	Baicalein	Rabbit	Ischemia, small clot embolic stroke model	Reduced behavioral deficits	(Lapchak et al., 2007)
9	Nordihydroguai aretic acid	Rat	Ischemia, transient 4- vessel occlusion	Reduced the post ischemic neuronal death , improved behavioral deficits	(Shishido et al., 2001)
10	Caffeic acid	Rat	Ischemia, transient MCAO	Attenuated brain atrophy, infarct volume, and astrocyte proliferation	(Zhou et al., 2006)
11	Baicalein	Mice, primary cortical neurons	Ischemia, transient MCAO	Reduced glutamate-induced death of primary neurons. Decreased infarct size in mice. ischemia	(van Leyen et al., 2006)
12	Baicalein	Rat	Ischemia,, permanent MCAO	Improved neurological deficit, reduced brain water content and infarct size	(Cui et al., 2010)
13	Baicalein, CDC, AA861	organotypic cultures of rat hippocam pal slices	Oxygen glucose deprivation	Attenuation of neuronal damage	(Arai et al., 2001)
14	BW755C	Rat	SCI	Improved neurological recovery	(Faden et al., 1988)
15	Phenidone	Rat	Stroke-prone spontaneously hypertensive rats	Prolonged stroke free survival	(Munsiff et al., 1992)