Table 2.

Baseline and Follow-up Assessments (T1 – T6): Self-report or blinded Independent Assessors

Domain	Measure
Psychiatric Diagnosis	SCID at baseline, MINI/PRIME-MD at every three months in follow-up (Note: The MINI/PRIME-MD is used to assess syndromal depression and anxiety disorders at every follow-up).
Knee Osteoarthritis Diagnosis	American College of Rheumatology clinical criteria for knee osteoarthritis at baseline
Depression severity	Patient Health Questionnare-9 (PHQ-9)*
Anxiety	Generalized Anxiety Disorder-7 (GAD-7)*
Medical burden/Medication Check List/Vitals	Cumulative Illness Rating Scale (CIRS-G)** Cornell Service Index* Medication List Update* Vitals (Weight, Blood pressure, Hip and Waist Circumference, History of Falls)** Alcohol Use Disorders Identification Test (AUDIT-C)*
Disability	Late-Life Functional Disability Inventory (LL-FDI) *
Functional status, physical performance	Short Physical Performance Battery (SPPB) **
Insomnia	Pittsburgh Sleep Quality Index (PSQI)*
Overall Body Pain	Numeric Rating Scale for Pain (NRS-20)*
Knee Pain and Disability	Western Ontario and McMaster University Arthritis Index (WOMAC)* Patient Global Assessment of Functioning* Patient Global Assessment of Pain Severity* Catastrophizing Subscale of the Coping Strategies Questionnaire**
Cognitive Status	Repeatable Battery for the Assessment of Neuropsychological Status** Delis-Kaplan Executive Function System** Modified Mini Mental State Examination at baseline
Social Isolation/Support	Interpersonal Support Evaluation List*
Problem Solving Skills	Social Problem Solving Inventory (SPSI)**
Biosignatures	Inflammatory Cytokines* (IL6, TNF alpha) + mRNA Transcription (blood draw)* Genetic data only collected at T1
Global Health	Patient Global Impression of Change (PGIC)* RAND-12* Physical Activity Scale for the Elderly (PASE)*
Satisfaction	5 questions to rate satisfaction plus comment field administered at study Completion

^*Baseline and every three months in follow-up

^**Baseline and every six months in follow-up