Skip to main content
. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Anesthesiology. 2016 Jun;124(6):1311–1327. doi: 10.1097/ALN.0000000000001111

Figure 4. Anesthesia causes significant post-translational changes in cAMP-responsive element binding protein (CBP) in the immature hippocampus.

Figure 4

(A) Anesthesia induces significant increase in the 148 kDa CBP in the developing hippocampus at 24 h as compared with age- matched controls (n=6; *, p=0.021) suggestive of enhanced fragmentation. (B) Anesthesia causes significant decrease in CBP histone acetylase (HAT) activity at 24 h (*, p=0.026) in developing hippocampus as compared with age-matched controls (n=3). (C) Anesthesia causes significant increase in the expression of fragmented lamin (41-50 kDa), a chromatin organization component and well-known substrate of activated caspase-6 (n=4, *, p=0.029).