Table 3.

Association of antibodies and risk of ASD, EMA study, births 2000–2001.

	OR${}_{\mathrm{\text{adj}}}^{\mathrm{\text{a}}}$	95% CI	OR${}_{\mathrm{\text{adj}}}^{\mathrm{\text{b}}}$	95% CI	OR${}_{\mathrm{\text{adj}}}^{\mathrm{\text{c}}}$	95% CI
MATERNAL
Total IgG
Q4 vs. Q1	0.92	(0.39, 2.17)	0.87	(0.37, 2.08)	0.89	(0.37, 2.13)
Q3 vs. Q1	1.41	(0.63, 3.14)	1.39	(0.62, 3.12)	1.34	(0.59, 3.01)
Q2 vs. Q1	0.53	(0.22, 1.30)	0.51	(0.21, 1.25)	0.51	(0.21, 1.27)
Total IgM
Q4 vs. Q1	0.46	(0.17, 1.27)	0.44	(0.16, 1.23)	0.42	(0.15, 1.21)
Q3 vs. Q1	0.63	(0.25, 1.61)	0.63	(0.25, 1.60)	0.71	(0.27, 1.85)
Q2 vs. Q1	0.68	(0.29, 1.62)	0.69	(0.29, 1.66)	0.75	(0.31, 1.82)
Toxo IgG
CAT4 vs. CAT1*	0.35	(0.13, 0.91)	0.33	(0.12, 0.86)	0.40	(0.15, 1.11)
CAT3 vs. CAT1*	0.58	(0.25, 1.32)	0.53	(0.22, 1.24)	0.55	(0.23, 1.30)
CAT2 vs. CAT1*	0.86	(0.40, 1.86)	0.83	(0.38, 1.81)	0.86	(0.39, 1.87)
Toxo IgM
Q4 vs. Q1	0.80	(0.32, 1.99)	0.78	(0.31, 1.94)	0.71	(0.28, 1.77)
Q3 vs. Q1	0.82	(0.36, 1.84)	0.78	(0.34, 1.78)	0.70	(0.30, 1.64)
Q2 vs. Q1	0.78	(0.33, 1.84)	0.74	(0.31, 1.78)	0.69	(0.28, 1.69)
NEWBORN
Total IgG
Q4 vs. Q1	0.77	(0.31, 1.89)	0.76	(0.31, 1.86)	0.70	(0.28, 1.76)
Q3 vs. Q1	0.65	(0.28, 1.48)	0.61	(0.27, 1.42)	0.64	(0.27, 1.48)
Q2 vs. Q1	0.75	(0.33, 1.69)	0.72	(0.32, 1.65)	0.72	(0.31, 1.66)
Total IgM
HIGH vs. LOW**	0.67	(0.30, 1.49)	0.67	(0.30, 1.48)	0.77	(0.34, 1.75)
Toxo IgG
Q4 vs. Q1	0.25	(0.08, 0.79)	0.25	(0.08, 0.78)	0.31	(0.10, 1.01)
Q3 vs. Q1	0.89	(0.41, 1.94)	0.90	(0.41, 1.96)	0.87	(0.39, 1.92)
Q2 vs. Q1	0.52	(0.23, 1.17)	0.52	(0.23, 1.18)	0.50	(0.22, 1.14)

^aAdjusted for laboratory plate, maternal age, maternal education.

^bAdjusted for laboratory plate, maternal age, maternal education, maternal race/ethnicity (White non-Hisp., White Hisp., Other).

^cAdjusted for laboratory plate, maternal age, maternal education, maternal race/ethnicity (White non-Hisp., White Hisp.-US Born, White Hisp.-Not US Born, Other).

^*Reference category (CAT1) only includes signals at the MDL. Values above the MDL divided into 3 equal-sized categories based on control values.

^**Reference category (LOW) includes all signals above but close to the minimum observed value for the assay, with remaining values lumped into one higher category.

Bold means statistically significant.