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. 2016 May 18;10:124. doi: 10.3389/fncel.2016.00124

Figure 1.

Figure 1

Regional specific astroglial death in the hippocampus following status epilepticus (SE). (A) Astroglial responses in the molecular layer of the dentate gyrus. Massive astroglial loss is observed in this region 3 days and 1 week after SE. (B) TUNEL-positive apoptosis in the molecular layer of the dentate gyrus 3 days after SE. (C) Astroglial responses in the CA1 region following SE. (D) LAMP1-positive clasmatodendrosis (round-shaped edematous cell body, short blunt processes, loss of distal processes, GFAP aggregation, nuclear dissolution and LAMP-1 positive vacuolization) in this region 4 weeks after SE. Bar = 100 (A,C) and 25 μm (B,D). (E) Quantification of the fraction of TUNEL-positive astrocytes in the total astrocytes within the molecular layer of the dentate gyrus following SE (mean ± SD, n = 7, respectively). *p < 0.05 vs. non-SE animals. (F) Quantification of the fraction of LAMP1-positive astrocytes in the total astrocytes within the CA1 region following SE (mean ± SD, n = 7, respectively). *p < 0.05 vs. non-SE animals.