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. 2016 May 18;10:130. doi: 10.3389/fncel.2016.00130

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Copyright © 2016 Hackert, Müller, Rohde, Bien, Köhling and Kirschstein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GABA_A receptor-mediated inhibitory postsynaptic currents (IPSCs) are intact in anti-GAD65 tissue. (A) Superimposed sample traces showing GABA_A receptor-dependent IPSCs before (black trace) and after 5 μM gabazine (gray trace). Lowercase letters indicate the current at the holding potential (a), stimulus artifact (b), GABA_AR-mediated IPSC (c), and stimulation-evoked trace after gabazine (d). (B) Whole-cell patch-clamp recordings confirmed that IPSCs evoked by near field stimulation were entirely GABA_A receptor-dependent. (C) Input-output relationship of GABA_AR-mediated IPSCs was not significantly different between anti-GAD65 and control tissues. (D) The current-voltage relationship revealed that the reversal potential for GABA_AR-mediated synaptic responses was indistinguishable between anti-GAD65-treated animals and controls.