Table 6.

Summary of anchor-based and distribution measures of minimal clinically important difference of three multi-item scales shared across C-CAP1 and C-CAP2

	Mean change score in three disease-specific multi-item C-CAP instruments anchored using a range of anchor measures of minimal important change				MCID (mean of anchors)	SEM (pre/post)	SDC (pre/post)
	Symptoms have become less frequent	Symptoms have become shorter	Patient expectations were met	Global health score (EQ-5D-5L) improvement of 20 points
Symptom severity (score range 0–45)	7.31	6.89	7.22	7.14	7.14	3.29/2.66	9.12/7.38
Frequency and duration (score range 0–8)	1.85	1.45	2.95	0.91	1.79	1.15/0.89	3.19/2.47
Impact on life (score range 0–30)	5.21	5.78	5.93	4.99	5.48	2.80/1.81	7.79/5.02

MCID, minimal clinically important difference; SDC, smallest detectable change; SEM, standard error of measurement