Table 6.
Summary of anchor-based and distribution measures of minimal clinically important difference of three multi-item scales shared across C-CAP1 and C-CAP2
| Mean change score in three disease-specific multi-item C-CAP instruments anchored using a range of anchor measures of minimal important change | MCID (mean of anchors) | SEM (pre/post) | SDC (pre/post) | ||||
|---|---|---|---|---|---|---|---|
| Symptoms have become less frequent | Symptoms have become shorter | Patient expectations were met | Global health score (EQ-5D-5L) improvement of 20 points | ||||
| Symptom severity (score range 0–45) | 7.31 | 6.89 | 7.22 | 7.14 | 7.14 | 3.29/2.66 | 9.12/7.38 |
| Frequency and duration (score range 0–8) | 1.85 | 1.45 | 2.95 | 0.91 | 1.79 | 1.15/0.89 | 3.19/2.47 |
| Impact on life (score range 0–30) | 5.21 | 5.78 | 5.93 | 4.99 | 5.48 | 2.80/1.81 | 7.79/5.02 |
MCID, minimal clinically important difference; SDC, smallest detectable change; SEM, standard error of measurement