Table 2.

The effects of CM and Met on bodyweight and fasting blood glucose levels in experimental rats.

			Initial	8-week HFHSD feeding	7-day STZ injection	4-week drug treatment
						1	2	3	4
Body weight (g)	CTRL	—	140.2 ± 25.1	445.3 ± 33.9	468.3 ± 32.8	464.3 ± 29.8	470.3 ± 30.9	480.2 ± 28.4	485.2 ± 32.4
	Model	—	139.2 ± 26.8	450.1 ± 35.9	386.2 ± 35.1#	326.0 ± 39.1##	315.7 ± 25.9##	303.9 ± 38.8##	297.0 ± 32.4##
	CM (g/kg)	0.5	145.1 ± 29.2	455.3 ± 33.8	381.7 ± 31.5#	348.3 ± 32.7##	339.2 ± 42.1#	347.9 ± 59.2#	361.7 ± 27.8#∗
		1	143.2 ± 30.7	456.3 ± 30.0	388.6 ± 30.5#	320.0 ± 42.6##	335.7 ± 41.1#	355.9 ± 31.9#	373.7 ± 30.2#∗
		2	140.1 ± 25.1	475.1 ± 35.9	385.1 ± 31.9#	373.8 ± 23.5#	355.2 ± 28.9#	345.2 ± 30.7#	390.0 ± 22.0#∗
	Met (mg/kg)	100	139.6 ± 22.1	462.4 ± 32.3	391.9 ± 30.2#	326.4 ± 37.9##	345.1 ± 32.1#	344.0 ± 38.2#	349.0 ± 35.6#∗
Fasting blood glucose (mmol/L)	CTRL	—	4.1 ± 0.7	4.3 ± 0.6	4.6 ± 0.8	4.6 ± 0.7	4.7 ± 0.6	4.7 ± 0.9	4.8 ± 0.7
	Model	—	4.2 ± 0.6	4.6 ± 0.5	18.1 ± 1.5##	19.2 ± 1.4##	19.1 ± 2.2##	21.0 ± 1.9##	18.9 ± 1.9##
	CM (g/kg)	0.5	4.0 ± 0.5	4.5 ± 0.7	18.3 ± 1.6##	15.2 ± 2.1##	13.7 ± 1.7##	12.3 ± 1.9#∗	10.8 ± 1.8#∗
		1	3.9 ± 0.7	4.2 ± 0.9	17.7 ± 1.6##	16.1 ± 1.7##	13.9 ± 1.4##	11.6 ± 1.7#∗	12.2 ± 1.9#∗
		2	4.1 ± 0.7	4.5 ± 0.6	18.0 ± 2.1##	14.8 ± 1.6##	12.5 ± 1.9##	11.9 ± 1.9#∗	12.7 ± 1.7##∗
	Met (mg/kg)	100	4.2 ± 0.613	4.4 ± 0.7	17.6 ± 2.1##	17.1 ± 2.1##	14.7 ± 1.6##	13.8 ± 1.7##∗	12.9 ± 1.8#∗

Data are expressed as mean ± SEM (n = 6) and analyzed using one-way ANOVA. ^# P < 0.05 and ^## P < 0.01 versus normal controls. ^∗ P < 0.05 versus model group.