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. 2016 May 18;6:26119. doi: 10.1038/srep26119

Figure 2. ApoE4xAPP mice exhibited spatial memory impairment at 26 weeks.

Figure 2

(A) At 26 weeks, there were no significance differences in the number of errors made during the learning trials (1–16) among APP, ApoE3xAPP and ApoE4xAPP mice (One-way ANOVA, F = 0.07862, 0.5190, 0.8266, 0.2743, respectively). ApoE4xAPP mice made more errors compared to ApoE3xAPP mice during the short term (#p < 0.05) and long term memory trials (##p < 0.01) (One-way ANOVA, F = 3.368, 5.854, respectively, Tukey-Kramer). (B) At 52 weeks, the ApoE4xAPP mice made significantly more errors than ApoE3xAPP mice during trials 13–16 (#p < 0.05) (One-way ANOVA, F = 3.398, Tukey-Kramer). During the short-term probe trial, ApoE4xAPP mice made significantly more errors than APP (**p < 0.01) and ApoE3xAPP (##p < 0.01) mice (One-way ANOVA, F = 15.21, Tukey-Kramer) During the long-term memory probe trial, ApoE4xAPP mice made significantly more errors than APP (**p < 0.01) and ApoE3xAPP (##p < 0.01) mice, while ApoE3xAPP mice made significantly less errors than APP mice (*p < 0.05) (One-way ANOVA, F = 14.23, Tukey-Kramer). (C) At 78 weeks, ApoE4xAPP mice made more mistakes than ApoE3xAPP mice during trials 5–8 (##p < 0.01) and 9–12 (##p < 0.01) (One-way ANOVA, F = 7.127, F = 8.425, respectively, Tukey-Kramer). During trials 13–16, ApoE4xAPP mice made more errors than APP (*p < 0.05) and ApoE3xAPP mice (##p < 0.01) (One-way ANOVA, F = 7.834, Tukey-Kramer). During the short-term memory and long-term memory probe trials, ApoE4xAPP mice made more errors than APP (*p < 0.05) and ApoE3xAPP mice (##p < 0.01). However, ApoE3xAPP mice made less errors than APP mice (**p < 0.01) (One-way ANOVA, F = 26.16, F = 68.56, respectively, Tukey-Kramer). Error bars represent ± SEM (n = 7–10).