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. 2016 May 18;6:26119. doi: 10.1038/srep26119

Figure 5. Insulin stimulation increased mEPSC amplitudes but did not rescue Aβ42-induced down-regulation of AMPA mEPSC frequencies and amplitudes in both ApoE3 and ApoE4 neurons.

Figure 5

(A) mEPSC interval histograms from ApoE3 and ApoE4 hippocampal neurons. Insulin treatment has no effect on mEPSC intervals while Aβ42 pre-treatment significantly increased mEPSC intervals in both ApoE3 and ApoE4 neurons (One-way ANOVA, F = 26.40,17.32 respectively). In both ApoE3 and ApoE4 neurons, Aβ42 (**p < 0.01) and Aβ42+Ins (##p < 0.01) treated neurons showed significant increases in mEPSC intervals when compared to other treatment groups (Tukey-Kramer). (B) mEPSC amplitude histograms from ApoE3 and ApoE4 hippocampal neurons. Insulin treatment increased mEPSC amplitudes in both ApoE3 and ApoE4 neurons (**p < 0.01, *p < 0.05) (One-way ANOVA, F = 11.17, 5.722, respectively, Tukey-Kramer). (C) Summary of post-hoc Tukey-Kramer analysis. Error bars represent ± SEM (n = 6). NT refers to no treatment.