Figure 2. Intravenous administration of lidocaine decreases the noxious response induced by peripheral pinch stimuli.

(a) Intravenous lidocaine (10 mg/kg) suppressed evoked excitatory postsynaptic currents (EPSCs) induced by peripheral pinch stimuli in a reversible manner. (b) Schematic diagrams showing areas under the curve. Analysis of the area surrounded by the baseline and border of EPSCs was performed with Clampfit10 software. (b) The area under the curve was significantly decreased by intravenous lidocaine (10 mg/kg) compared with controls both 10 and 15 min after administration. n = 12, *P < 0.05 compared to controls by Student’s paired t-test.