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. 2016 May 18;6:26253. doi: 10.1038/srep26253

Figure 4. Intravenous administration of lidocaine decreases the frequency of miniature EPSCs without changing their amplitude.

Figure 4

(a) Presented is an example of the effect of intravenous lidocaine on excitatory postsynaptic currents (EPSCs) in the presence of tetrodotoxin (TTX). After spinal superfusion of TTX (0.5 μM), the EPSCs elicited by peripheral pinch stimuli disappeared completely and large amplitudes of EPSCs were also inhibited. Intravenous lidocaine (10 mg/kg) reduced the frequency of miniature EPSCs. In contrast, intravenous lidocaine had no effect on the amplitude of miniature EPSCs. Downward arrows indicate outtakes of the top trace shown on an expanded timescale. Lidocaine was administered for 3 min from the arrowhead. (b) Average frequency and amplitude of miniature EPSCs in the presence of lidocaine (10 mg/kg) relative to controls are shown as a function of time (mean ± standard error of the mean, n = 10). (c) Intravenous lidocaine (10 mg/kg) significantly shifts the cumulative distribution of the inter-event intervals to the right (P < 0.01, Kolmogorov-Smirnov test) (left graph). In contrast, it has no effect on the cumulative distribution of the amplitudes (P = 0.59) (right graph).