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. 2016 May 18;6:26253. doi: 10.1038/srep26253

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(a) Intravenous lidocaine (10 mg/kg) produces an outward current at a holding potential of −70 mV. Traces below are shown on an expanded time scale. Lidocaine was administered for 3 min from the arrowhead. (b) Intravenous lidocaine induces an outward current in SG neurons. The average amplitude of the intravenous lidocaine (10 mg/kg)-induced outward current was larger than that of lidocaine (1 mg/kg). *P < 0.05 compared to 1 mg/kg group by one-way analysis of variance (ANOVA).