Table 1. Demographic and clinical characteristics of the included colorectal adenomas.
| General Characteristics | Paneth cell status | Paneth cell status-3 categories | |||||||
|---|---|---|---|---|---|---|---|---|---|
| sum | Absence | Presence | P-value | Absence | Present in proximal colon | Present in distal colorectum | P-value | ||
| Age, year | |||||||||
| <39 | 20 | 18 (90) | 2 (10) | 0.005* | 18 (90) | 2 (10) | 0 | 0.027* | |
| 40–49 | 115 | 98 (85.22) | 17 (14.78) | 98 (85.22) | 13 (11.3) | 4 (3.48) | |||
| 50–59 | 681 | 572 (83.99) | 109 (16.01) | 572 (83.99) | 86 (12.63) | 23 (3.38) | |||
| 60–69 | 629 | 512 (81.40) | 117 (18.60) | 512 (81.40) | 84 (13.35) | 33 (5.25) | |||
| >70 | 455 | 344 (75.60) | 111 (24.40) | 344 (75.60) | 80 (17.58) | 31 (6.81) | |||
| Gender | |||||||||
| Female | 785 | 650 (82.8) | 135 (17.2) | 0.149 | 650 (82.8) | 96 (12.23) | 39 (4.97) | 0.191 | |
| Male | 1,115 | 894 (80.18) | 221 (19.82) | 894 (80.18) | 169 (15.16) | 52 (4.66) | |||
| History of CRC | Positive | 37 | 32 (86.49) | 5 (13.51) | 0.526* | 32 (86.49) | 1 (2.7) | 4 (10.81) | 0.027* |
| Negative | 1863 | 1512 (81.16) | 351 (18.84) | 1512 (81.16) | 264 (14.17) | 87 (4.67) | |||
| History of AA or CRC | Positive | 169 | 150 (88.76) | 19 (11.24) | 0.009 | 150 (88.76) | 13 (7.69) | 6 (3.55) | 0.029 |
| Negative | 1731 | 1394 (80.53) | 337 (19.47) | 1394 (80.53) | 252 (14.56) | 85 (4.91) | |||
| Synchronous CRC | Positive | 16 | 16 (100) | 0 | 0.054* | 16 (100) | 0 | 0 | 0.222* |
| Negative | 1884 | 1528 (81.1) | 356 (18.9) | 1528 (81.1) | 265 (14.07) | 91 (4.83) | |||
| Presence of a Synchronous AA or CRC | Positive | 222 | 191 (86.04) | 31 (13.96) | 0.052 | 191 (86.04) | 26 (11.71) | 5 (2.25) | 0.082* |
| Negative | 1678 | 1353 (80.63) | 325 (19.37) | 1353 (80.63) | 239 (14.24) | 86 (5.13) | |||
| Race | White | 1489 | 1208 (81.13) | 281 (18.87) | 0.894 | 1208 (81.13) | 218 (14.64) | 63 (4.23) | 0.151* |
| Hispanic | 16 | 14 (87.5) | 2 (12.5) | 14 (87.5) | 2 (12.5) | 0 | |||
| African American | 40 | 34 (85) | 6 (15) | 34 (85) | 2 (5) | 4 (10) | |||
| Asian | 209 | 167 (79.9) | 42 (20.1) | 167 (79.9) | 26 (12.44) | 16 (7.66) | |||
| Location | Right colon | 760 | 567 (74.61) | 193 (25.39) | <0.001 | 567 (74.61) | 193 (25.39) | 0 | NA |
| Transverse colon | 346 | 279 (80.64) | 67 (19.36) | 279 (80.64) | 67 (19.36) | 0 | |||
| Distal colorectum | 772 | 681 (88.21) | 91 (11.79) | 681 (88.21) | 0 | 91 (11.79) | |||
| Sum | 1900 | 1544 (81.26%) | 356 (18.74) | 1544 (81.26%) | 265 (13.95) | 91 (4.79) | |||
Note: All P-values were calculated using Chi-square test; CRC: Colorectal carcinoma; AA: advanced adenoma; (*) Fisher’s exact test used.