Table 2. Factors associated with the presence of synchronous advanced adenomas or carcinoma in patients with colorectal adenoma.
| Factor | Univariate | Multivariable model 1 (N = 1878) | Multivariable model 2 (N = 1878) | ||||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | ||
| Age, year | 60 + vs<60 | 1.78 (1.39–2.28) | <0.001 | 1.60 (1.18–2.17) | 0.002 | 1.59 (1.17–2.15) | 0.003 |
| 65 + vs <65 | 1.58 (1.25–2.01) | <0.001 | |||||
| Gender | Male vs Female | 1.3 (1.02–1.66) | 0.032 | 1.42 (1.05–1.92) | 0.021 | 1.43 (1.06–1.93) | 0.019 |
| History of CRC | Yes vs None | 1.09 (0.43–2.76) | 0.85 | ||||
| History of AA or CRC | Yes vs None | 2.83 (2.02–3.98) | <0.001 | 2.31 (1.55–3.45) | <0.001 | 2.30 (1.54–3.44) | <0.001 |
| Race | 0.92 (0.80–1.04) | 0.184 | |||||
| Location of Adenoma | Distal vs Proximal colon | 0.89 (0.78–1.01) | 0.072 | 1.05 (0.89–1.25) | 0.55 | 1.01 (0.86–1.19) | 0.088 |
| PC Status | Present vs Absent | 0.68 (0.45–1.00) | 0.054 | 0.67 (0.44–1.01) | 0.054 | ||
| PC Status–3 Categories | PC in proximal colon vs No PC | 0.77 (0.5–1.19) | 0.237 | 0.79 (0.50–1.26) | 0.33 | ||
| PC in distal colorectum vs no PC | 0.41 (0.17–1.03) | 0.057 | 0.39 (0.15–0.98) | 0.046 | |||
Note: AA: advanced adenoma; OR: Odds ratio; CI: confidence intervals; CRC: Colorectal carcinoma; PC: Paneth Cells; vs: versus.