Table 2.

The pharmacokinetic properties of the available triptans

Drug	Formulation	Dosage (mg)	Maximum 24 h dose (mg)	Time of peak levels	Elimination half life (H)	Bioavailability (%)
Sumatriptan	SI	6	6	12 min	2	97
	OT	50–100	200	2–3 h	2	15
	NS	20	40	1 h	2	17
Rizatriptan	ODT	10	30	1–2 h	2	14
Zolmitriptan	ODT	2.5	10	3 h	2.5–3	40–50
Almotriptan	OT	12.5	12.5	1.5–2 h	3.5	70
Eletriptan	OT	40	80	1.5–2 h	4	50
Naratriptan	OT	2.5	5	2–3 h	6	60–70
frovatriptan	OT	2.5	7.5	2–4 h	26	20–40

SI subcutaneous injection, OT oral tablet, NS nasal spray, ODT oral dispersible tablet, min minutes, h hour