Table 3.

Multivariate analysis of prognostic factors for patients randomized to intraperitoneal chemotherapy.

	N	Nevent	Adj. HR (PFS)			P value	Nevent	Adj. HR (OS)			P value
Age years	428	347	0.99	1.00	1.02	0.464	308	1.00	1.02	1.03	0.012
Race/ethnicity
White	390	321	Referent			–	284	Referent			–
Black	21	18	0.65	1.10	1.88	0.720	17	0.74	1.29	2.24	0.369
Other	17	8	0.25	0.57	1.30	0.182	7	0.30	0.70	1.61	0.399
Performance status
0	302	240	Referent			–	211	Referent			–
1	103	86	0.81	1.15	1.62	0.441	78	0.76	1.10	1.59	0.610
2	23	21	0.77	1.34	2.35	0.306	19	0.88	1.61	2.92	0.121
Histology
Serous adenocarcinoma	298	248	Referent			–	217	Referent			–
Endometrioid	49	31	0.43	0.69	1.12	0.131	27	0.46	0.77	1.28	0.310
Mixed epithelial	35	27	0.59	0.94	1.48	0.788	26	0.59	0.94	1.50	0.795
Clear-cell carcinoma	19	18	1.64	2.97	5.37	<0.001	18	2.27	4.20	7.74	<0.001
Other	27	23	0.57	0.95	1.59	0.846	20	0.53	0.92	1.58	0.755
Surgical stage
IIIA	23	12	Referent			–	11	Referent			–
IIIB	46	38	1.07	2.28	4.88	0.033	31	0.75	1.71	3.91	0.200
IIIC	336	278	0.94	2.05	4.49	0.071	251	0.90	2.04	4.65	0.089
Tumor grade
1	49	33	Referent			–	27	Referent			–
2	164	136	0.69	1.11	1.78	0.664	122	0.70	1.16	1.91	0.565
3	215	178	0.66	1.04	1.65	0.854	159	0.66	1.07	1.74	0.787
Lymph node status
Negative	121	90	Referent			–	80	Referent			–
Positive	133	106	0.64	0.98	1.51	0.941	91	0.58	0.90	1.38	0.622
Unknown	174	151	0.77	1.16	1.75	0.484	137	0.64	0.97	1.48	0.900
Residual disease
Microscopic	125	81	Referent			–	68	Referent			–
≤0.5 cm	172	153	1.19	1.64	2.26	0.002	143	1.34	1.87	2.62	b0.001
>0.5 cm	55	51	1.20	1.80	2.70	0.005	44	1.31	2.03	3.15	0.001

a b c represent the lower 95% confidence limit a, the value b, and the upper 95% confidence limit c.