Table 1.

Instruments and Syndromes for Identifying Psychosis Risk

	Measures	Syndromes	Symptoms	Frequency (Duration)	Onset
Clinical High Risk	SIPS2	Attenuated Positive Symptom Syndrome (APSS)	1 or more elevated sub-threshold positive symptom	≥ 1x/week in the past month.	Past year or worsened compared to 1 year ago
		Brief Intermittent Psychotic Syndrome (BIPS)	Briefly and recently met psychotic threshold on one or more positive symptom	1x/month (Present at least several minutes a day) up to 4x/week	Past 3 months
		Genetic Risk and Decline (GRD)	Schizotypal Personality Disorder Diagnosis or 1st degree relative with a psychotic disorder and a current Global Assessment of Functioning (GAF) score at least 30% lower than 12 months ago
	CAARMS19	Attenuated Psychosis Group (Subthreshold Intensity) (APG) Attenuated Psychosis Group (Subthreshold Frequency)	Elevated sub-threshold Unusual Thought Content (UTC), Non-Bizarre Ideas (NBI), Disorganized Speech (DS) or Perceptional Abnormalities (PA) and a 30% drop in SOFAS in the past year or a SOFAS ≤ 50 for the past year	1x/month to 2x/week (> 1 hour per occasion) or 3- 6x/week (<1 hour per occasion) to continuous (for at least a week)	Past 12 months but no more than 5 years ago
			Psychotic intensity on UTC or NBI or DS or Severe/Psychotic intensity on PA and a 30% drop in SOFAS in the past year or SOFAS ≤ 50 for the past year	1x/month to 2x/week (> 1 hour per occasion) or 3- 6x/week (<1 hour per occasion)	Past 12 months but < 5 years
		Brief Limited Intermittent Psychotic Symptoms (BLIPS)	Psychotic intensity on UTC or NBI or DS or Severe/Psychotic intensity on PA and a 30% drop in SOFAS in the past year or a SOFAS ≤ 50 for the past year	3-6x/week (>1 hour per occasion) or daily (<1 hour per occasion) to continuous (for at least a week)	Occurred during the last 12 months
		Vulnerability Group	Schizotypal Personality Disorder Diagnosis or 1st degree relative with a psychotic disorder and a 30% drop in SOFAS in the past year or a SOFAS < 50 for the past year
Basic Symptoms	SPI-A20	Cognitive Disturbances (COGDIS)	At least 2 of the following: (Inability to Divide Attention; Thought Interference; Thought Pressure; Thought Blockages; Disturbance of Receptive Speech; Disturbance of Expressive Speech; Unstable Ideas of Reference; Disturbances of Abstract Thinking; Captivation of Attention by Details of the Visual Field)	Weekly to daily	Last 3 months and 1st occurrence more than 12 months ago

Note: SIPS = Structured Interview for Psychosis-Risk Syndromes; CAARMS = Comprehensive Assessment of At-Risk Mental States; SPI-A = Schizophrenia Prediction Instrument for Adults; SOFAS: Social and Occupational Functioning Assessment Scale