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. 2016 May 18;6:26173. doi: 10.1038/srep26173

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Copyright © 2016, Macmillan Publishers Limited

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(A) Time to onset of epileptic seizures was reduced 7 days after MCAO. This effect was antagonized by gaboxadol (THIP), specifically activating extrasynaptic δ-GABA_ARs. THIP had no effect in control mice. Bars represent the mean ± s.e.m. [control (n = 6), control + THIP (n = 6), MCAO (n = 11), MCAO + THIP (n = 10), *p ≤ 0.05, **p ≤ 0.01]. (B) Time to onset of epileptic seizures was also reduced in GABRD^+/− mice compared to their wild-type littermates (GABRD^+/+). Bars represent the mean ± s.e.m. [GABRD^+/+ (n = 4), GABRD^+/− (n = 9), *p ≤ 0.05].