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. 2016 May 18;6:26059. doi: 10.1038/srep26059

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(A,B) TUNEL staining (pink) showed that intravitreal injection of Macugen resulted in apoptosis in the outer nuclear layer (ONL) of mouse retinae. (C,D) Co-injection of VEGF-B with Macugen markedly reduced the number of apoptotic cells in the mouse retinae. Two-tailed Student’s t-tests were performed using independent samples. ***P < 0.001.