Table 2. . Commercialized microfabricated cell chips.

Companyname	Brief device description	2D vs 3D culture	Structured co-culture	Signal detection method	Device materials	Scalable for mid† to high‡ throughput screening	Static or Perfusive	One example of highlighted functions	Ref.
ACEA Biosciences	Multiple-well format with embedded gold electrodes using impedance measurement to detect cell proliferation and migration	2D culture	No	Impedance	Mutiple well plastic culture plates	Yes	Static	Label-free cell analysis	[84]
AIM Biotech	3 microchannels side-by-side separated by micropilars with the center channel for 3D hydrogel culture and two side channels for medium feeding; three units on a microscope slide (75 mm × 25 mm)	3D (center); 2D (side channels)	Yes	Fluorescence by microscopic imaging	Gas permeable polymer on the bottom	Difficult	Perfusive	Angiogenesis study in tumor	[3]
Bell Brook Labs	Multiple microchannels connected with passive pumping wells enabled by surface tension	2D or 3D	No	Fluorescence by microscopic imaging	192 microchannels from PMMA or PDMS	Mid throughput	Static	iuvoMicroconduit Array Platform	[85]
Cellasic bought by Millipore	CellASIC® ONIX Microfluidic Plates, 4 independent open wells on a 96-well plate with multiple inlets for each well	3D or 2D	No	Fluorescence by microscopic imaging	Glass bottom	Difficult	Perfusive	Compatible for mammalian, yeast and bacteria culture	[86]
Cytoo	3D cell culture matrix created by micropatterning	3D	Possible	Fluorescence by microscopic imaging	Glass bottom	Possible	Static	3D cell culture on patterned surface	[87]
Celsee Diagnostics	On-chip circulating tumor cell (CTC) capture, grow and gene-level analysis	Similar to suspension culture	No	Fluorescence by microscopic imaging	Plastic chip	Difficult	Perfusive	CTC	[88]
Fluxion Biosciences	6∼24 samples per multiple-well plate format with flow, could handle adhesive cells and liquid samples	2D culture	No	Fluorescence by microscopic imaging	Glass bottom	Difficult	Perfusive	Flow shear stress study on cells	[89]
Xona microfluidics	2 channels separated by different width of grooves allowing axons and dendrites to be fluidically isolated from cell bodies	2D culture	Possible	Fluorescence by microscopic imaging	PDMS chambers with glass bottom	Difficult	Static or short term Perfusive	Neuron cell culture with microgrooves axons and dendrites separated from cell body	[90]

^†Mid throughput: a couple of hundred compounds.

^‡High-throughput: a couple of thousand compounds.