Table 1.

Metabolites that changed significantly (p ≤ 0.05) on at least two different days of analysis during the seven-day culture cycle in the HP vs. the control cells. Data derived from Additional file 3: Table S5. More details are avilable at: https://mynotebook.labarchives.com/share/ulav72/MjIuMXwxNzEzMTkvMTcvVHJlZU5vZGUvMzg1Mzg2MTkxNHw1Ni4x

Up 2, 4 and 6 day	Down 2, 4 and 6 day	Up 2 and 4 or 4 and 6 or 2 and 6 day	Down 2 and 4 or 4 and 6 or 2 and 6 day
1,3-Dexadecanoylglycerol	Tritriacontanol	Gluconic acid	Hexadecanoic acid
Adenosine	Hexadecanoic acid, 1-[[oxy]methyl]-1,2-ethanediyl ester	Pyruvic acid	Inositol-P
Alanine	Eicosanoic acid	Serine	9,12-Octadecadienoic acid
B-alanine	Pentadecanoic acid	Ribose	Guanine
Amino-isobutyric acid	Tetracosanoic acid	2-Methylserine	Glucose-6-phosphate
Cadaverine	Triacontanoic acid	2-Aminobutyric acid	Pyroglutamic acid
Ethanolamine	Butylamine	2-Aminoethyl-phosphate	Methylthioadenosine
GABA	Glutamic acid	9-Octadecenoic acid	Homocysteine
Galactosamine	Glutamine	Pipecolic acid	Lysine
Glucosamine	Histidine	2-O-Glycerol-α-D-galactopyranoside
Hydroxylamine	Inosine	Glucaric acid
Putrescine	Leucine
Suberylglycine	Methionine
Uracil	N-Acetyl-glucosylamine
Urea	N-Acetylglutamate
Galactopyranose	N-Acetyl-Lysine
1-Aminocyclopropane-carboxylic acid	Phenylalanine
Arabinoic acid lactone	Threonine
Galactaric acid	Tyrosine
Galactonic acid	Aconitic acid
Hydroxymalonic caid	Citric acid
2-Indolecarboxylic acid	3-Hydroxymethyl-glutaric acid
Malonic acid	2-Keto-gluconic acid
Succinic acid	Lactic acid
Digaactosylglycerol	Malic acid
Fructose	Quinolinic aci
Galactofuranose	Shikimic acid
Galactopyranose	Xylonic acid, lactone
Galactose	1,6-Anhydroglucose
Glucose	Fructofuranoside
1-Methyl-α-D-galactopyranoside	Gentiobiose