Table 1.

Association of miR-452 expression with clinicopathological factors in osteosarcoma

Clinicopathological features	Number of cases	miR-452 expression		P
		High	Low
		n (%)	n (%)
Age
<20 years	70	33 (47.1 %)	37 (52.9 %)	0.352
≥20 years	25	15 (60.0 %)	10 (40.0 %)
Gender
Male	68	35 (51.5 %)	33 (48.5 %)	0.823
Female	27	13 (48.1 %)	14 (51.9 %)
Tumor size
>8 cm	39	14 (35.9 %)	25 (64.1 %)	0.012
≤8 cm	56	34 (60.7 %)	22 (39.3 %)
Anatomic location
Tibia/femur	66	31 (47.0 %)	35 (53.0 %)	0.374
Elsewhere	29	17 (58.6 %)	12 (41.4 %)
Tumor grade
Low	31	22 (71.0 %)	9 (29.0 %)	0.008
High	64	26 (40.6 %)	38 (59.4 %)
Histological type
Osteoblastic	33	19 (57.6 %)	14 (42.4 %)	0.830
Fibroblastic	21	10 (47.6 %)	11 (52.4 %)
Chondroblastic	14	6 (42.9 %)	8 (57.1 %)
Telangiectatic	15	8 (53.3 %)	7 (46.7 %)
Others	12	5 (41.7 %)	7 (58.3 %)
Enneking stage
I	24	20 (83.3 %)	4 (16.7 %)	<0.001
II	48	23 (47.9 %)	25 (52.1 %)
III	23	5 (21.7 %)	18 (78.3 %)
Distant metastasis
Absent	72	43 (59.7 %)	29 (40.3 %)	0.001
Present	23	5 (21.7 %)	18 (78.3 %)