Table 1.

SULT1A1 Substrate Synergies and Catalytic Efficiencies

acceptor	Kd (μM)		synergy	kcat (s−1)	Km (μM)	efficiency
	E	E·PAP	Kd E/Kd E·PAP			kcat/Km (μM−1 s−1)
E2a	1.0	0.9	0.90	1.2	1.0	1.2
DHEAb	0.68	0.74	0.91	0.75	0.77	0.97
Resc	1.1	0.85	1.4	1.5	1.6	0.93
Acetd	0.50	0.018	28	100	0.022	4500
1-Nape	1.3	0.07	18	100	0.077	1300
2-Napf	1.5	0.06	25	110	0.063	1700
APg	0.88	0.047	20	58	0.051	1100
1-HPh	5.5	0.019	290	120	0.018	3300

^aE₂, estradiol.

^bDHEA, dehydroepiandrosterone.

^cRes, resveratrol.

^dAcet, acetaminophen.

^e1-Nap, 1-naphthol.

^f2-Nap, 2-naphthol.

^gAP, apomorphine.

^h1-HP, 1-hydroxypyrene.