Table 2.

Ligand Binding to Wild-Type and Mutant SULT1A1

SULT1A1	Kd (μM)a
	E2		fulvestrant		PAP	2-Nap
	E	E·PAP	E	E·PAP	E	E	E·PAP
WT	1.0 (0.1)	0.9 (0.2)	1.7 (0.3)	35 (4)	0.27 (0.02)	1.7 (0.3)	0.077 (0.02)
V243G	0.9 (0.1)	1.6 (0.2)	1.3 (0.2)	1.5 (0.3)	0.28 (0.01)	2.2 (0.2)	2.7 (0.3)
F255A	0.9 (0.2)	0.9 (0.2)	1.5 (0.1)	1.4 (0.2)	0.27 (0.02)	2.0 (0.2)	1.7 (0.3)
D249S	0.9 (0.1)	1.5 (0.3)	1.6 (0.2)	1.2 (0.3)	0.30 (0.01)	2.2 (0.2)	2.1 (0.3)
I89A	1.5 (0.3)	1.6 (0.2)	1.1 (0.1)	22 (3)	0.31 (0.04)	1.8 (0.1)	1.9 (0.2)

^aParentheses enclose standard error estimates.