TABLE 3.
Total and cause-specific mortality according to plasma phospholipid 20:0, 22:0, and 24:0 among Cardiovascular Health Study Participants1
| Quintiles of concentrations |
||||||
| 1 | 2 | 3 | 4 | 5 | P-trend | |
| 20:0 | ||||||
| Total mortality | ||||||
| Person-years | 8458 | 9141 | 9180 | 9255 | 9415 | |
| Cases, n | 661 | 627 | 629 | 611 | 606 | |
| Age- and sex-adjusted | 1.0 (ref) | 0.84 (0.75, 0.94) | 0.86 (0.77, 0.96) | 0.84 (0.75, 0.93) | 0.86 (0.77, 0.96) | 0.02 |
| Additionally adjusted2 | 1.0 (ref) | 0.92 (0.83, 1.03) | 0.92 (0.82, 1.03) | 0.92 (0.82, 1.03) | 0.94 (0.83, 1.05) | 0.30 |
| Non-CVD mortality | ||||||
| Cases, n | 383 | 387 | 388 | 376 | 380 | |
| Age- and sex-adjusted | 1.0 (ref) | 0.89 (0.77, 1.03) | 0.91 (0.79, 1.05) | 0.88 (0.76, 1.01) | 0.92 (0.80, 1.06) | 0.28 |
| Additionally adjusted2 | 1.0 (ref) | 0.96 (0.83, 1.10) | 0.96 (0.83, 1.11) | 0.95 (0.82, 1.10) | 0.98 (0.84, 1.13) | 0.78 |
| CVD mortality | ||||||
| Cases, n | 278 | 238 | 240 | 235 | 225 | |
| Age- and sex-adjusted | 1.0 (ref) | 0.77 (0.64, 0.91) | 0.79 (0.67, 0.94) | 0.78 (0.65, 0.93) | 0.78 (0.66, 0.94) | 0.02 |
| Additionally adjusted2 | 1.0 (ref) | 0.87 (0.73, 1.04) | 0.86 (0.72, 1.03) | 0.88 (0.73, 1.05) | 0.87 (0.73, 1.05) | 0.18 |
| 22:0 | ||||||
| Total mortality | ||||||
| Person-years | 8096 | 8432 | 9360 | 9738 | 9823 | |
| Cases, n | 674 | 651 | 621 | 597 | 591 | |
| Age- and sex-adjusted | 1.0 (ref) | 0.89 (0.80, 0.99) | 0.77 (0.69, 0.86) | 0.71 (0.63, 0.79) | 0.78 (0.70, 0.87) | <0.0001 |
| Additionally adjusted2 | 1.0 (ref) | 0.90 (0.80, 1.00) | 0.86 (0.77, 0.97) | 0.75 (0.67, 0.84) | 0.85 (0.75, 0.95) | <0.0001 |
| Non-CVD mortality | ||||||
| Cases, n | 401 | 393 | 388 | 354 | 378 | |
| Age- and sex-adjusted | 1.0 (ref) | 0.90 (0.78, 1.03) | 0.80 (0.69, 0.92) | 0.70 (0.60, 0.80) | 0.83 (0.72, 0.95) | <0.0001 |
| Additionally adjusted2 | 1.0 (ref) | 0.90 (0.78, 1.03) | 0.87 (0.76, 1.01) | 0.74 (0.64, 0.86) | 0.88 (0.76, 1.01) | 0.006 |
| CVD mortality | ||||||
| Cases, n | 272 | 258 | 232 | 242 | 212 | |
| Age- and sex-adjusted | 1.0 (ref) | 0.88 (0.74, 1.04) | 0.73 (0.61, 0.86) | 0.73 (0.61, 0.86) | 0.72 (0.60, 0.86) | <0.0001 |
| Additionally adjusted2 | 1.0 (ref) | 0.90 (0.76, 1.07) | 0.85 (0.71, 1.02) | 0.77 (0.65, 0.92) | 0.80 (0.66, 0.96) | 0.003 |
| 24:0 | ||||||
| Total mortality | ||||||
| Person-years | 8126 | 8713 | 9003 | 9674 | 9934 | |
| Cases, n | 672 | 656 | 615 | 599 | 592 | |
| Age- and sex-adjusted | 1.0 (ref) | 0.86 (0.77, 0.96) | 0.78 (0.70, 0.87) | 0.68 (0.61, 0.76) | 0.70 (0.63, 0.79) | <0.0001 |
| Additionally adjusted2 | 1.0 (ref) | 0.93 (0.83, 1.04) | 0.83 (0.75, 0.93) | 0.79 (0.71, 0.89) | 0.80 (0.71, 0.90) | <0.0001 |
| Non-CVD mortality | ||||||
| Cases, n | 401 | 387 | 376 | 364 | 386 | |
| Age- and sex-adjusted | 1.0 (ref) | 0.85 (0.74, 0.98) | 0.80 (0.69, 0.92) | 0.69 (0.60, 0.80) | 0.76 (0.66, 0.88) | <0.0001 |
| Additionally adjusted2 | 1.0 (ref) | 0.90 (0.78, 1.04) | 0.83 (0.72, 0.96) | 0.79 (0.68, 0.91) | 0.85 (0.73, 0.98) | 0.006 |
| CVD mortality | ||||||
| Cases, n | 270 | 268 | 239 | 234 | 205 | |
| Age- and sex-adjusted | 1.0 (ref) | 0.88 (0.74, 1.04) | 0.76 (0.64, 0.90) | 0.67 (0.56, 0.80) | 0.61 (0.51, 0.74) | <0.0001 |
| Additionally adjusted2 | 1.0 (ref) | 0.98 (0.83, 1.16) | 0.85 (0.71, 1.01) | 0.81 (0.67, 0.97) | 0.72 (0.60, 0.87) | <0.0001 |
1
Values are HRs (95% CIs), n = 3941. Data were analyzed using Cox regression. CVD, cardiovascular disease; ref, reference.
2
Additionally adjusted for race, clinic, education, smoking, alcohol use, BMI, waist circumference, physical activity, treated hypertension, prevalent diabetes, prevalent cardiovascular disease, self-reported prevalent cancer, and self-reported health status at baseline.