Table 3.
Clinical, Hormonal, and Metabolic Features of Patients Before and After Bariatric Surgery
| Variable | Presurgery | 3 Months Postsurgery | Significance | 6 months Postsurgery | Significance |
|---|---|---|---|---|---|
| BMI (kg/m2) | 44.4 (37.6 to − 68.6) | 36.9 (29.8–56.5) | <.0001 | 33.9 (28–50.2) | <.0001 |
| Weight (kg) | 125.6 (102–169.2) | 103.9 (83.9–139.4) | <.0001 | 95.9 (79–123.8) | <.0001 |
| AST (IU/liter) | 18.9 (10–42) | 19.4 (10–56) | .8 | 20.8 (12–77) | .7 |
| ALT (IU/liter) | 27.1 (7–81) | 21.4 (7–70) | .3 | 22.6 (7–133) | .4 |
| Total cholesterol (mg/dl) | 167.4 (129–213) | 157.1 (110–200) | .1 | 165.5 (109–213) | .9 |
| Triglycerides (mg/dl) | 135.3 (40–305) | 108.3 (54–204) | .1 | 104.7 (43–217) | .06 |
| HDL cholesterol (mg/dl) | 50.1 (27–78) | 46.4 (29–90) | .6 | 52.9 (34–98) | .2 |
| LDL cholesterol (mg/dl) | 90.8 (46–140) | 87.6 (32–142) | .7 | 91.0 (28–125) | .9 |
| Glucose (mg/dl) | 108.8 (77–247) | 104.8 (66–199) | .6 | 98.6 (73–181) | .14 |
| Insulin (uU/ml) | 7.4 (0.4–17.9) | 10 (1–30.9) | .2 | 7.4 (0.9–24) | .9 |
| HOMA-IR | 1.98 (0.1–5) | 2.6 (0.4–7.8) | .3 | 1.4 (0.3–3.3) | .12 |
| HbA1c (%) | 6.3 (4.7–9.9) | 5.5 (4.8–6.1) | .6 | 5.4 (4.7–6.3) | .01 |
| Adiponectin (ng/ml) | 6021 (3394–10 202) | 12 739 (7258–26 778) | <.0001 | 16 404 (7623–30 928) | <.0001 |
| CTRP9 (ng/ml) | 120.6 (68–176) | 92.3 (47–169) | .002 | 92 (40.8–142) | <.0001 |
| Leptin (pg/ml) | 84 899 (1826–490 825) | 24 347 (4756–58 356) | .005 | 19 775 (3875–44 729) | .004 |
Data are means, with range. P values calculated by paired t test, in comparison to baseline.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase.