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. 2016 Mar 16;157(5):2052–2066. doi: 10.1210/en.2015-1958

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Figure 5. — CO effects on PVN VP neuronal activity in HF rats are dependent on NO signaling. A1, Summary of the incidence of PVN VP neuronal responses to the HO inhibitor SnPP (20μM) in slices pretreated with the NOS inhibitor LNAME (2mM) plus an NO scavenger (carboxy-PTIO) (100μM) in sham (n = 15) and HF (n = 14) rats. Graphs summarizing the mean effects of HO inhibition in the presence of LNAME+carboxy-PTIO on the firing activity of VP neurons in sham (A2) and HF (A3) rats. B1, Summary of incidence of PVN VP neuronal responses to the CO donor CORM (30μM) in slices pretreated with LNAME plus NO scavenger in sham (n = 14) and HF (n = 13) rats. Graphs summarizing the mean effects of CO donor in the presence of LNAME+carboxy-PTIO on the firing activity of VP neurons in sham (B2) and HF (B3) rats. Note that in the absence of NO, CO actions were blunted. Data are reported as the mean ± SEM. Student's paired t test.