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. 2016 Mar 18;157(5):1789–1798. doi: 10.1210/en.2015-1965

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This article has been published under the terms of the Creative Commons Attribution License (CC-BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

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Figure 3. — Weight and survival in Men1^+/− mice. A, Mean monthly weight of mice in the PBS-treated (open circles) and pasireotide-treated (closed circles) groups (n = 24–70). The pasireotide-treated Men1^+/− mice did not gain weight when compared with the PBS-treated Men1^+/− mice (*, P < .05; **, P < .01). Error bars represent SEM. B, Kaplan-Meier analysis of mortality rates in Men1^+/− mice during the 21 mo of study. Forty-seven of 72 PBS-treated Men1^+/− mice (65.2%) survived until age 21 mo, compared with 51 of 63 pasireotide-treated mice (80.9%). Thus, survival in pasireotide-treated Men1^+/− mice was significantly higher at age 21 mo, compared with control PBS-treated Men1^+/− mice (P < .05, log-rank Mantel-Cox test).