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. 2016 Mar 18;157(5):1789–1798. doi: 10.1210/en.2015-1965

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This article has been published under the terms of the Creative Commons Attribution License (CC-BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

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Figure 5. — Assessment by immunohistochemical analysis of effects of pasireotide on proliferation in Men1^+/− mice pituitary NETs and pancreatic NETs. Pituitary and pancreatic NETs obtained from control PBS-treated Men1^+/− mice are compared with pasireotide-treated Men1^+/− mice, after administration of BrdU for 4 wk. A, Pituitary NET-adjacent sections from Men1^+/− mice stained with H&E and immunostained for prolactin (green) and BrdU (red). Nuclei were counterstained with DAPI (Blue). The NETs are circled by dashed lines (black in the H&E sections and white in the fluorescent immunohistochemical sections). The large pituitary NETs from a PBS-treated Men1^+/− mouse and a pasireotide-treated Men1^+/− mouse showing immunostaining for prolactin but not GH (data not shown), are highly proliferating (red nuclei), although there are fewer proliferating cells in the pituitary NETs of the pasireotide-treated mouse. B, Pancreatic NET-adjacent sections from Men1^+/− mice stained with H&E and immunostained for insulin (green) and BrdU (red), and counterstained for nuclei (blue). The NETs are circled by dashed lines (black in the H&E sections and white in the fluorescent immunohistochemical sections). The pancreatic NET from the pasireotide-treated Men1^+/− mouse had fewer proliferating cells. Scale bar = 100 μm.