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. 2016 Mar 18;157(5):1789–1798. doi: 10.1210/en.2015-1965

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This article has been published under the terms of the Creative Commons Attribution License (CC-BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

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Figure 6. — Proliferation and apoptosis of pancreatic and pituitary NETs in Men1^+/− mice. Proliferative and apoptotic rates were assessed by BrdU labeling and TUNEL assays, respectively. Pancreatic and pituitary NETs were collected from Men1^+/− mice age 21 mo given BrdU for 28 d before necropsy. The proliferation and apoptotic rates were compared between PBS and pasireotide-treated mice. A, Proliferation rates in pancreatic and pituitary NETs from PBS-treated Men1^+/− mice (open bars) (n = 36 sections from six mice) and pasireotide-treated Men1^+/− mice (filled bars) (n = 36 sections from six mice). B, Apoptotic rates in pancreatic and pituitary NETs from PBS-treated Men1^+/− mice (open bars) (n = 19 pancreatic NET sections from three mice, and 40 pituitary NET sections from five mice) and pasireotide-treated Men1^+/− mice (filled bars) (n = 21 pancreatic NET sections from five mice, and 39 pituitary NET sections from six mice). Pancreatic and pituitary NETs demonstrated a significant 4-fold increase in apoptosis with pasireotide treatment when compared with PBS-treatment. Error bars represent SEM; ***, P < .001.