Table 2.
Arterial Values in Ambient, Oxygenated, and Hypoxemic GSIS Studies
| Study Period | Ambient Oxygen Tension |
Oxygenation |
Hypoxemia |
|||||
|---|---|---|---|---|---|---|---|---|
| Intact-Control (n = 7) | AD-Control (n = 7) | Intact-IUGR (n = 7) | AD-IUGR (n = 5) | Intact-IUGR (n = 7) | AD-IUGR (n = 5) | Intact-Control (n = 7) | AD-Control (n = 7) | |
| Basal | ||||||||
| O2 content, mmol/L | 3.8 ± 0.1a | 3.0 ± 0.1b | 2.1 ± 0.2c | 1.8 ± 0.2c | 3.5 ± 0.2d | 3.4 ± 0.3d | 1.3 ± 0.1d | 1.2 ± 0.1d |
| PaCO2, mm Hg | 47.4 ± 0.5a | 51.6 ± 0.6b | 51.3 ± 1.3b | 54.4 ± 1.1b | 49.9 ± 0.9 | 54.1 ± 1.3 | 40.9 ± 0.7d | 46.4 ± 1.3d,e |
| pH | 7.30 ± 0.01a,b | 7.30 ± 0.01a,b | 7.32 ± 0.01a | 7.28 ± 0.01b | 7.35 ± 0.01d,e | 7.29 ± 0.01 | 7.28 ± 0.01 | 7.28 ± 0.01 |
| Hematocrit, % | 33.8 ± 0.5a | 35.7 ± 1.3a,b | 42.5 ± 1.5c | 40.9 ± 1.9b,c | 38.5 ± 1.7d | 37.5 ± 2.0d | 36.1 ± 0.4d | 37.6 ± 0.9d |
| Bicarbonate, mmol/L | 21.2 ± 0.3 | 22.1 ± 0.3 | 22.2 ± 0.4 | 21.3 ± 0.3 | 24.5 ± 0.4d,e | 22.1 ± 0.3d | 17.5 ± 0.7d | 18.6 ± 0.5d |
| Lactate, mmol/L | 1.62 ± 0.09a | 2.68 ± 0.18a,b | 2.84 ± 0.19a,b | 3.84 ± 0.50b | 4.30 ± 0.83d | 4.42 ± 0.91 | 8.15 ± 0.96d | 8.20 ± 0.83d |
| Hyperglycemic | ||||||||
| O2 content, mmol/L | 3.5 ± 0.1a,f | 2.9 ± 0.1b,f | 1.3 ± 0.1c,f | 1.6 ± 0.1c,f | 2.6 ± 0.2d | 3.0 ± 0.3d | 1.2 ± 0.1d | 1.2 ± 0.1d |
| PaCO2, mm Hg | 48.5 ± 0.6a | 52.4 ± 0.9a,b | 54.5 ± 0.8b,f | 56.5 ± 1.2b,f | 54.5 ± 1.2 | 56.4 ± 1.2 | 40.0 ± 0.6d | 48.8 ± 1.2d,e |
| pH | 7.29 ± 0.01a,f | 7.29 ± 0.01a,f | 7.26 ± 0.01a,b,f | 7.25 ± 0.01b,f | 7.31 ± 0.01d,e | 7.27 ± 0.01 | 7.16 ± 0.02d | 7.16 ± 0.03d |
| Hematocrit, % | 33.4 ± 0.5a | 35.5 ± 1.2a,b | 40.9 ± 1.4b | 40.2 ± 1.8b | 38.2 ± 1.6d | 36.9 ± 2.0d | 35.0 ± 0.4d | 35.7 ± 0.9e |
| Bicarbonate, mmol/L | 20.6 ± 0.3f | 21.5 ± 0.2f | 19.9 ± 0.4f | 20.0 ± 0.3f | 23.1 ± 0.4d | 21.7 ± 0.4d | 13.3 ± 0.8d | 14.9 ± 0.9d |
| Lactate, mmol/L | 2.18 ± 0.09a,f | 3.05 ± 0.15a,f | 5.70 ± 0.34b,f | 5.23 ± 0.57b,f | 4.38 ± 0.62d | 4.30 ± 0.76 | 13.36 ± 1.39d | 12.44 ± 1.28d |
a-c
Letter superscripts denote differences (P ≤ .05) within the period of the ambient oxygen tension study.
d
Differences (P ≤ .05) within the period between GSIS studies (oxygenation or hypoxemia) vs ambient oxygen tension data.
e
Treatment differences (P ≤ .05) within steady-state periods for the reverse oxygen tension GSIS studies.
f
Differences (P ≤ .05) between steady state periods within treatment group for the ambient GSIS study.