Table 2.

Phenotypic Data for HIMS Cohort

HIMS Cohort	Wild Type (n = 3568)	P300L (n = 98)	P Value
IGF-1, ng/mL	134.0 (101–172)a	120.0 (91–165)a	.037a
IGFBP-3, mg/L	3.8 ± 0.9	3.7 ± 1.0	.25
Height, cm	171.9 ± 6.7	173.0 ± 6.4	.13
BMI, kg/m2	26.6 ± 3.7	26.7 ± 3.8	.73
Age, y	77.1 ± 3.6	76.9 ± 3.5	.57

Abbreviation: BMI, body mass index. In the HIMS cohort, carriers of P300L have lower circulating IGF-1 levels. The table shows the values for individuals with heterozygous P300L or WT GRP94. IGF-1 values were distributed in non-Gaussian fashion, so the interquartile ranges are given and comparisons were made using the nonparametric Mann-Whitney U test. IGFBP-3, body mass index, and height were distributed normally, and thus, these comparisons were made using an independent-samples Student's t test.

^aComparisons were made using the nonparametric Mann-Whitney U test.