Table II.

Clinical and Laboratory Findings for Test Cohort

ID	EVD Day	Organism	Medium	Quantity	Systemic Infection	Tmax (degrees Celsius)	Sxms	CSF RBC (cells/ mm³)	CSF WBC & Prior CSF WBC (cells/ mm³)	CSF PMN (%)	CSF Protein (mg/dL)	CSF Glc (mg/dL)	Serum Glc (mg/dL)	Serum WBC (K/ul)	Gram Stain	#	Treatment
N1	5	S.epi	Liquid	--	No	36.9	No	2,320	2 (2)	88	13	96	131	15.3	No	1	IV x 2 days
N2	2	P.acnes	Liquid	--	No	36.8	No	878	18 (N/A)	6	<10	89	89	11	No	1	No
N2*	2	MSSA	Liquid	--	No	36.6	No	132,000	2200 (N/A)	92	361	77	149	12.2	No	1	IV x 2 days
N3	5	Bacillus	Solid	Innum	No	36.8	HA/N	150	0 (1)	N/A	<10	84	117	13.9	GVR	4	IV x 14 days, IT x 5 days
N4	1	P.acnes	Liquid	--	No	37.4	No	3,103	145 (2860)	77	45	76	90	12.1	No	1	No
N5	14	S.epi	Solid	Many	No	35.7	No	73	3 (3)	N/A	33	65	115	10	No	1	IV x 10 days
N6	6	Klebsiella	Solid	Mod	Klebsiella UTI	37.6	AMS	737,000	1730 (305)	79	733	111	174	14.9	No	3	IV x 22 days
N7	9	S.epi	Liquid	--	Enterobacter PNA	38.8	No	390	1 (1)	N/A	31	89	130	9.7	No	1	No
N8	5	Serratia	Solid	Mod	No	38.6	No	17,000	107 (11)	83	159	48	105	11.8	No	19	IV x 37 days
M1	16	Providencia Rettgeri	Solid	Mod	E.coli PNA	39.4	No	533	411 (603)	83	67	92	205	12.7	Few GNR	1	IV x 10 days
M2	4	CN Staph	Solid	Rare	PNA	38.3	No	196,000	940 (N/A)	85	176	53	139	10.8	Mod PMN	2	IV x 23 days
M3	8	P.acnes	Solid	--	E.coli UTI	39.4	No	9,125	295 (13)	61	72	86	164	15.2	No	1	No
M4	6	Acinetobacter	Solid	Mod	PNA (No organism)	39.1	No	N/A	256 (44)	77	60	78	120	24.7	Mod GNR	1	IV x 22 days
M5	14	Propionibact	Liquid	--	No	38.4	No	1,397	6 (1,190)	32	14	72	144	12.1	No	1	IV x 21 days
M6	13	Enterobacter Aerogenes	Solid	Abund	No	38.9	HA/Nuch	32,500	1,550 (N/A)	92	233	64	172	8.1	Abund PMN	1	IV x 16 days
M7	18+1	Klebsiella	Solid	--	No	39.3	No	744	13,700 (640)	90	820	< 2	106	9.6	Abund PMN	1	IV x 14 days
M8	9	CN Staph	Solid	--	No	39.2	No	3,400	71 (26)	82	117	40	177	10.7	No	1	IV x 30 days
M8*	17	GNR	Solid	Abund	CN Staph Ventriculitis	N/A	No	328	117 (1975)	76	126	< 2	149	7.6	Abund GNR	1	IV x 30 days

ID=identification (values that begin with N are New York University patients and those that begin with M are Massachusetts General Hospital patients), *=patients with positive cultures that grew two distinct organisms (N2 had positive cultures on two separate admissions and M8 grew two different organisms at different times on the same admission), ICH=intracranial hemorrhage, SAH=subarachnoid hemorrhage, IVH=intraventricular hemorrhage, EVD=external ventricular drain, EVD Day= number of days EVD was in place (placement day = day 1; patients who were diagnosed with infection after EVD removal are denoted at EVD day of removal + number of days after removal), S.epi= Staphylococcus epidermidis, P.acnes= Propionibacterium acnes, MSSA=Methicillin Sensitive Staphylococcus aureus, CN staph=coagulase negative Staphylococcus, E.coli=Escherichia coli, Propionibact=Propionibacterium species, Quantity= not available for organisms that grew in liquid only (and in some cases no data on quantity was available for organisms that grew on solid media), Innum=innumerable bacteria, Mod=moderate, Abund=abundant, Systemic Infection=presence of systemic infection on day of positive culture, UTI=urinary tract infection, PNA=pneumonia, Tmax=maximum temperature in the 24 hours prior to the culture, Sxms=symptoms not attributed or possibly worse than would be attributed to primary pathology, HA=headache, N=nausea, AMS=altered mental status, Nuch=nuchal rigidity, CSF=cerebrospinal fluid, WBC=white blood cells, PMN=polymorphic neutrophils, N/A=not applicable (no results available), Glc=glucose, GVR=gram variable rods, GNR=gram negative rods, #=number of positive cultures with the same organism, IV=intravenous antibiotics, IT= intrathecal antibiotics