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. 2016 Apr;11(4):617–622. doi: 10.4103/1673-5374.180747

Figure 3.

Figure 3

Expression of BDNF mRNA in cerebral cortex after tail-vein injection of different liposomes at high and low doses (reverse transcription-polymerase chain reaction).

(A, B) Tf-pGFAP-BDNF-PEG and Tf-pCMV-BDNF-PEG at different doses: BDNF mRNA expression was greater in the high-dose groups than in the low-dose groups (*P < 0.05, **P < 0.01). (C, D) Tf-pGFAP-BDNF-PEG and Tf-pCMV-BDNF-PEG groups at 2 μg (C) or 10 μg (D); BDNF mRNA expression was higher in the Tf-pGFAP-BDNF-PEG group than in the Tf-pCMV-BDNF-PEG group at both doses (#P < 0.05, ##P < 0.05). Data are presented as the mean ± SD (10 rats in each group; one-way analysis of variance followed by the least significant difference-t test). BDNF: Brain-derived neurotrophic factor; Tf: transferrin; pGFAP: glial fibrillary acidic protein promoter; PEG: polyethylene glycol; pCMV: cytomegalovirus promoter.