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26 year-old male with Rosai-Dorfman disease of the epidural thoracic spine.
Findings: Histologic and immunohistochemical assessment demonstrating macrophages ingesting leukocytes (emperipolesis). A) Hematoxylin and Eosin staining of case show a mixed inflammatory infiltrate with a foamy macrophage containing other lymphoid cells (arrow). B) S-100 staining of sample showing positive cytoplasmic staining of foamy macrophage with emperipolesis. Bar= 100 um.
