Fig. 1.
Serotonin receptor 2C (HTR2C) gene amplified by real-time polymerase chain reaction (PCR) from knock-out mice (lane 2) and controls (lane 3). Lane 1 shows molecular weight markers. Contemporary amplification of the housekeeping GAPDH gene was also performed (data not shown). Amplification kinetics, which showed an increase in expression in the hypoxanthine-guanine phosphoribosyl-transferase gene (HPRT) knock-out mice brains compared to controls, were obtained by analysing PCR samples at different steps (25, 27, 29, 30, 33 cycles).