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. Author manuscript; available in PMC: 2017 May 4.
Published in final edited form as: J Am Chem Soc. 2016 Apr 26;138(17):5467–5478. doi: 10.1021/jacs.6b02019

Scheme 4.

Scheme 4

Formal synthesis of premisakinolide A and C(19)–C(32) of swinholide A via site-selective C-H allylation and crotylation of unprotected diols.a

aFor graphical summaries of prior syntheses, see Supporting Information.